Another study suggested that APOE activates LILRB4 and modulates the SHP2/NF-κB/urokinase plasminogen activator receptor (UPAR)/Arginase-1 (ARG1) axis (Figure 3A), facilitating AML cell migration, infiltration, and T-cell suppression 22. This evidence concerns the gene ARG1 and acute myeloid leukemia.