ARHGEF12 and neoplasm: Since integrins play a crucial role in mediating exosome functions, particularly in guiding exosomes to distant organs to form a pre-metastatic niche and further support organ-specific metastasis 45, 46, and our RNA-Seq results revealed that ARHGEF12 upregulates integrins expression, we hypothesized that integrins mediate tumor-derived exosomes.