C9orf72 and amyotrophic lateral sclerosis: To investigate the downstream effector mechanisms through which astrocytic YAP regulates neuronal loss and motor deficits in C9orf72-poly-GA mice, we analyzed single-nucleus transcriptomic (snRNA-seq) data from motor cortex samples of C9orf72-ALS/FTD patients with low and high YAP expression 68, along with RNA sequencing (RNA-seq) results from cultured YAP+/+ and YAP-/- (YAP knockout) astrocytes 54.