Based on these previous studies and our results (Figure 7 and Supplementary Figure S3), it is possible that early in ALS pathogenesis, Wnts are secreted from neurons and/or astrocytes during neurodegeneration, then in turn activate the YAP/β-catenin/EAAT2 signaling pathway in astrocytes. Here, SLC1A2 is linked to amyotrophic lateral sclerosis.