By integrating the snRNA-seq of C9orf72-ALS/FTD patients with low and high YAP expression, and RNA-seq from cultured YAP+/+ and YAP-/- astrocytes, we found that the most differential pathway was enriched in neurotransmitter uptake (Figure 5A-B). The gene discussed is C9orf72; the disease is frontotemporal dementia.