WNT3A and amyotrophic lateral sclerosis: It has been reported that the expression of Wnt1, Wnt2, Wnt3a and Wnt7a is upregulated in SOD1G93A mice, and in ALS, motor neurons, astrocytes, microglia and oligodendrocytes exhibit high levels of Wnt/β-catenin signaling and β-catenin activation 37, 38.