WNT3A and melanoma: Interestingly, Riluzole treatment upregulates the Wnt3a expression in melanoma cells in vitro, and enhances the Wnt/β-catenin signaling in both HT22 neuronal cells and adult hippocampal progenitor cells 82, 83, suggesting that Riluzole is an enhancer of the Wnt/β-catenin signaling.