The expression of Yes-associated protein (YAP) and Collagen Type I Alpha 2 Chain (COL1A2), proteins that correlated with cellular mechanics, were reduced in cells treated with RGD@LP-Y (Figure 1G), and the level of COL1 secreted by cells was also decreased (Figure 1H), which suggests that the matrix stiffness of the tumor cells was reduced. The gene discussed is YAP1; the disease is neoplasm.