COL1A2 and neoplasm: The expression of Yes-associated protein (YAP) and Collagen Type I Alpha 2 Chain (COL1A2), proteins that correlated with cellular mechanics, were reduced in cells treated with RGD@LP-Y (Figure 1G), and the level of COL1 secreted by cells was also decreased (Figure 1H), which suggests that the matrix stiffness of the tumor cells was reduced.