In contrast, NSUN2 posttranscriptionally enhances PD-L1 mRNA stability, subsequently increasing PD-L1 expression in an m5C-ALYREF-dependent manner and providing protective effects for tumour cells against CD8+ T-cell-mediated cytotoxicity in NSCLC 146. The gene discussed is NSUN2; the disease is non-small cell lung carcinoma.