IFNG and colorectal cancer: This finding aligns with findings in colorectal cancer, where APOL3-induced ferroptosis increases CD8+ T-cell infiltration and effector function 53, and with the findings of Liao et al., who reported that CD8+ T-cell-derived IFN-γ upregulates ACSL4 to increase ferroptosis and antitumor activity in melanoma 31.