ANXA2 and melanoma: Conversely, CRISPR-mediated ANXA2 knockout (KO) in melanoma cells, achieved using ANXA2 sgRNA lentivirus transduction, substantially reduced ANXA2 expression (Figure S2H, top panel; Figure S2L, left panel), leading to elevated intracellular miR-150-3p levels (Figure S2L, left panel).