AGO2 and melanoma: AGO2-RIP-qRT‒PCR assays demonstrated that the NF2 and CISD3 mRNAs were markedly enriched in the AGO2-miR-150-3p complex (Figure 5F and Figure S7B), a finding corroborated by their upregulation in miR-150-3p knockout melanoma cells (Figure 5G and Figure S7C).