Moreover, in the two-hit experiment induced by the opportunistic strain F132 (Figure 6L), the bacterial load in lung tissues (1.0-log lower CFUs, p = 0.017) as well as distal organs liver (3.30-log lower CFUs, p = 0.001) and spleen (3.30-log lower CFUs, p = 0.009) of mice in CD11b-shArg2-mCherry group was significantly lowered in comparison to the CMV-mCherry group (Figure 6M), indicating a reduced susceptibility to secondary infections. This evidence concerns the gene ITGAM and infection.