The NLRP3 inflammasome is a double-edged sword: while its acute activation can drive anti-tumor immunity by promoting IL-1β/IL-18 secretion and immunogenic cell death, chronic or dysregulated NLRP3 signaling has been implicated in tumor-promoting inflammation, immunosuppressive microenvironment remodeling 32, and metastasis in certain contexts. The gene discussed is NLRP3; the disease is neoplasm.