Metabolomic features were extracted that allowed distinctions between glioma and normal tissues (at an area under the curve (AUC) of 0.932), isocitrate dehydrogenase (IDH) mutant and wildtype gliomas (at an AUC of 1.000), and IDH mutant gliomas and glioblastoma (at an AUC of 1.000). Here, IDH3A is linked to central nervous system cancer.