In contrast, IL-23-treated adipocytes harbored motifs related to pluripotency (Pou5f1, Pou4f2, Pou3f1, and Sox2) 35, adipogenesis (Nfatc2 and Nfat5) 36, 37, and obesity-associated metabolism (Irf1 and Nr3c1) 38 (Figure 6A). Here, SOX2 is linked to obesity due to melanocortin 4 receptor deficiency.