The cell cycle-related genes such as tumor protein p53 (P53), cyclin dependent kinase inhibitor 1A (P21), cyclin dependent kinase inhibitor 2A (P16), as well as SASPs including interleukin 1 beta (Il-1b), C-X-C motif chemokine receptor 2 (Cxcr2) and vascular endothelial growth factor A (Vegfa) were significantly upregulated with the administration of high dose of LIG in BDL- and CCl4-induced fibrosis model (Figure 3D-E). This evidence concerns the gene CDKN1A and fibrosis.