Moreover, in BDL-induced liver fibrosis model, the cellular senescence marker P16 were co-stained with the HSC maker, α-SMA (Figure 4B andFigure S8A), hepatocyte marker, ALB (Figure S8B) and the liver sinusoidal endothelial cell marker, LYVE1 (Figure S8C). Here, ACTA1 is linked to Hepatic fibrosis.