ACHE and Alzheimer disease: On the other hand, several studies showed that the PAS area of AChE could accelerate the polymerization of Aβ peptides, and its inhibition disrupted polymerization of these peptides.13 Therefore, interaction of the ChE inhibitors with the PAS component is also valuable for the management of AD.14 According to the presented points, the design of new ChE inhibitors with inhibitory activities against both AChE and BChE that interact with the PAS component of the binding sites of these enzymes has become particularly important for medicinal chemists.15