APP and Alzheimer disease: Heat shock protein β-1 (HSPB1), APP, and patient agewere found to accurately predict AD (area under curve (AUC) range= 0.91–0.96) using four brain proteomic data sets that includedAfrican American brain samples. Population-basedproteomic differences at baseline have crucial clinical managementramifications, albeit additional CP studies, are required that shouldinclude other ethnic minorities such as Hispanics, American Indians,and Alaska Natives.