Chondromodulin-I (ChM-I) 1 is a 25-kDa glycoprotein that was isolated from bovine cartilage and was shown to be a potent vascular endothelial cell growth inhibitor.56 It is expressed in a variety of organs, including the brain, and is known for its tumour suppressor functions in several cancers such as osteosarcomas,18,57 gastric adenocarcinoma58 and breast cancer.59 We can hypothesize that decreased expression of CNMD in FCD IIb through increased methylation can lead to cellular hyperplasia (i.e. Balloon cells). The gene discussed is CNMD; the disease is osteosarcoma.