Braun et al. 50 reported that blood (r = 0.85) had high proportion of individual CpGs significantly correlated with brain, and cortical regions showing stronger correlations than the cerebellum.47 The presence of IL1RAP, HIPK2, and CNMD methylation in both brain and blood samples suggests that gene-specific blood-based methylation analysis could possibly offer a minimally invasive method for diagnosing and differentiating FCD subtypes. The gene discussed is HIPK2; the disease is fleck corneal dystrophy.