TNF and neoplasm: Interestingly, a few patients did not show differences in prognosis based on variations in the degree of immune infiltration, so it was necessary to uncover the mechanism of other important factors such as nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) and tumor necrosis factor alpha (TNF‐α) pathways leading to resistance in immune‐enriched tumor microenvironment (TME) [25, 26].