Among them, Nrf2 is a core target that co‐occurs in all three diseases (MS, AD, and psychiatric disorders), while molecules such as IL‐3 (MS, AD), TGF‐β1 (MS, ALS), C1q (AD, ALS), CHI3L1 (MS, AD), and NMDAR (psychiatric disorders, HD) play a role in both diseases. This evidence concerns the gene TGFB1 and amyotrophic lateral sclerosis.