Despite all these clinical progressions, in contrast to PD‐L1, there are also substantial investigations suggesting that B7‐H3 on tumor cells plays crucial tumor cell‐intrinsic functions in enhancing survival and proliferation signaling pathways, including PI3K/Akt, Jak/STAT, NF‐κB‐p65/MAPK‐p38, and Ras/Raf/MEK [13, 14]. This evidence concerns the gene CD274 and neoplasm.