The exogenous expression of B7‐H3 also significantly enhanced the spheroid formation of HCT116 cells, a marker of CRC stemness feature [18], and this effect was significantly suppressed by either crizotinib, a c‐Met inhibitor, or cryptotanshinone, a STAT3 inhibitor (Figure 4B). The gene discussed is STAT3; the disease is colorectal carcinoma.