STAT3 and colorectal carcinoma: The addition of recombinant B7‐H3 protein of its extracellular domain triggered the Tyr1234/1235 phosphorylation of endogenous c‐Met in HCT116 (a CRC cell line) cells, a feature of c‐Met receptor activation and Tyr705 phosphorylation of STAT3, a core c‐Met downstream signaling molecule (Figure 4A, Figure S2A) [17].