LSMEM1 and lupus nephritis: For their small size enables multi‐pathway influence, a single micropeptide may concurrently affect metabolism, inflammation and apoptosis through distinct molecular interactions.[52, 53] These findings potentially explain LSMEM1's upregulated expression patterns observed across various renal pathologies including IgA nephropathy, lupus nephritis, and LPS‐induced septic AKI, though its most pronounced effects appear in highly energy‐dependent cell types like tubular epithelial cells and podocytes.