Previous studies have shown that LSMEM1 is up‐regulated in atherosclerotic heart disease, psoriasis,[4] prostate cancer[5] and Parkinson's disease,[6] and some studies have found that LSMEM1 gene mutations may drive primary bladder signet ring cell carcinoma.[7] However, the mechanism of LSMEM1 up‐regulation in diseases has not yet been comprehensively reported. The gene discussed is LSMEM1; the disease is carotid atherosclerosis.