STAT3 and non-small cell lung carcinoma: Another deletion in exon 25 (from G983 to L1038) was identified in the GBM and NSCLC patients, which was also constitutively phosphorylated and caused STAT3 activation in the absence of the ligand.[56, 103] Exon 25 spanning from G983 to L1038 encompasses the AP‐2 helix and the electrostatic hook, both of which contribute to the stabilization of the symmetric inactive TKD configuration.[15] Consequently, the deletion of exon 25 is likely to disrupt the stability of the inactive TKD, thereby shifting the balance of the TKD toward an asymmetric active configuration within the dimeric structure.