EGFR and neoplasm: designed a novel PTG‐T16R‐scFv‐CAR‐T cell targeting EGFR and B7 homolog 3 protein (B7H3), which simultaneously inhibited expression of PD‐1, TIM‐3, Tight, TGF‐β receptor, IL‐10 receptor, and IL‐6 receptor with multiple shRNA clusters, enabling CAR‐T cells to escape most of the interference of tumor cells.