Immunoglobulin‐like transcript 4 (ILT4) is another immune inhibitory receptor in the ILT superfamily, which is mainly expressed on myeloid cells, but it is also highly expressed on tumor cells.[244] In EGFRmut tumors, ILT4 was upregulated through the EGFR‐AKT‐ERK1/2 signaling, which induced recruitment and M2‐like polarization of TAMs, meanwhile blocked T cell infiltration and cytotoxicity, thereby promoting the formation of an immunosuppressive microenvironment.[245]. The gene discussed is EGFR; the disease is neoplasm.