CD4 and non-small cell lung carcinoma: compared single‐cell transcriptomic data from NSCLC patients with EGFRmut and EGFRwt, which showed reduced CXCL13‐producing follicular helper CD4+ T(TFH)‐like cells and tissue‐resident memory CD8+ T(TRM)‐like cells.[308] Using single‐cell RNA (sc‐RNA) and bulk RNA sequencing datasets of lung adenocarcinoma, CD8+ T cells and NK cells were found to decrease in EGFRmut samples relative to EGFRwt samples, whereas Tregs and myeloid cells showed an inverse tendency.[212] Tumor‐infiltrating lymphocytes (TILs) are often sparse or absent in EGFRmut tumors, resulting in impaired CD8+ T cell function.