Notably, CXCR2’s contribution to hypertension appears to originate from the immune compartment transplantation of CXCR2-deficient bone marrow into wildtype mice conferred protection against Ang II–induced vascular injury and hypertension, whereas transplantation of wildtype bone marrow into CXCR2-deficient mice did not. This evidence concerns the gene CXCR2 and Hypertension.