IL6 and major depressive disorder: In summary, the observed improvements in Ki67 levels, body composition, V̇O2peak, IL‐6, and depression in these two patients appear to align with trends reported in prior research (Banerjee et al., 2018; Chen, Wei, et al., 2022; Dunne et al., 2016; Karenovics et al., 2017; Khoramipour et al., 2024; Klavina et al., 2024; Rao et al., 2012; Tawara et al., 2019).