The in‐depth characterization performed by Sakane et al. highlighted the profound differences between the “original” DGKδ1, and the second splicing alternatives, DGKδ2, showing also different tissue expression patterns: DGKδ2 transcripts have been found in several healthy and tumor tissues, while the DGKδ1 ones were detected in a few compartments, that is, in the ovary and the spleen and certain cancer cells. The gene discussed is DGKD; the disease is cancer.