In melanoma cells for instance it helps to prevent apoptosis promoting NF‐κB activation via the PKCζ‐mediated Ser‐311 phosphorylation of p65/RelA [144, 171], while in hepatocellular carcinoma it sustains cell proliferation through the activation of the MAPK cascade [145], in non‐small cell lung cancer it promotes metastatic processes activating the SRC/FAK complex, modulating the WNT/β‐catenin and VEGF pathways [34]. Here, RELA is linked to melanoma.