In China, with the improvements in living standards, the incidence of diabetes mellitus has increased, and diabetes mellitus is accompanied by retinal microangiopathy, which threatens the health of patients and eventually leads to blindness.[31] This study was designed to investigate the protective effect of miR-218-enriched exosomes secreted by hUMSCs on VEGF-induced oxidative stress in HRECs to promote endothelial proliferation and migration and ameliorate endothelial cell dysfunction caused by VEGF. The gene discussed is VEGFA; the disease is Blindness.