Due to excessive exogenous thyroid hormone causing subclinical thyroid hyperfunction, it causes harm to the cardiovascular system and skeletal system, leading to arrhythmia, reduced bone mineral density, and increased risk of heart failure and fracture, as well as symptoms such as thinness, palpitations, and agitation.[52] Colostomy is a common treatment for patients with colorectal cancer. The gene discussed is TG; the disease is heart failure.