Our results indicate a negative correlation between Orexin A levels and insulin resistance in GDM patients, which is consistent with previous research suggesting that Orexin A may be implicated in glucose metabolism and energy homeostasis.[11,12] The exact mechanisms through which Orexin A influences insulin sensitivity remain to be fully elucidated; however, it is hypothesized that its role in regulating appetite and energy expenditure may contribute to the improvement of insulin resistance.[13]. This evidence concerns the gene INS and Insulin resistance.