Chiricosta et al reported that Moringin downregulates MAP1LC3B, PINK1, and other autophagy-related genes, thereby inhibiting mitophagy, reducing OS, and preventing apoptosis, which may contribute to alleviating periodontal disease-related tissue damage.[50] Our study revealed that VPS13C and MAP1LC3B are significantly upregulated in periodontal disease tissues compared to healthy tissues. This evidence concerns the gene VPS13C and periodontal disorder.