BCL2 and Parkinson disease: BNIP3L (BCL-2 Interacting Protein 3 Like), also known as NIX, is a member of the BCL-2 protein family and plays a critical role in regulating mitophagy and autophagy.[41] Through its BH3-only domain, BNIP3L interacts with BCL-2 and BCL-XL, inhibiting their antiapoptotic effects and thereby promoting autophagy.[42] Emerging evidence suggests that BNIP3L is significantly involved in the pathogenesis of PD, particularly in the regulation of mitophagy and apoptosis.