AFP and neoplasm: Since most patients with SPN have no specific symptoms, and most patients do not have abnormal tumor markers such as AFP, CEA, CA199, CA125, etc, and there are no diagnostic biomarkers for SPN, early, timely and accurate diagnosis of the disease remains a challenge.However, as more cases of SPN have been reported and knowledge of its pathology has increased, the understanding of its detection and diagnosis has also improved.