An excessive supply of saturated or unsaturated fatty acids can lead to ceramide accumulation, which reduces the activation of protein kinase B (PKB)/Akt, lowers glucose transporter type 4 expression, inhibits glucose uptake into cells, and disrupts insulin signaling, ultimately contributing to insulin resistance.[23] In a mouse study, clozapine administration was associated with hyperglycemia and reduced glycogen levels, and a rapid decrease in hepatic ceramide content was observed within the first hour. This evidence concerns the gene INS and Insulin resistance.