Disruption of this balance increases susceptibility to autoimmunity and infections.[36,37] In RA, immune complexes formed by autoantibodies such as rheumatoid factor and anti-cyclic citrullinated peptide antibodies activate immune cells through Fcγ receptor interactions, promoting an inflammatory response.[38] ADCY7, a membrane-bound isoform activated by extracellular signals, is pivotal in the catecholamine-stimulated lipolysis pathway. The gene discussed is ADCY7; the disease is infection.