In conclusion, our study identified critical genes associated with RA, including CKAP2, GABBR1, HLA-DPA1, ST6GAL1, FCGR1A, ADCY7, MAP4K1, CD37, ERAP2, SEMA3C, PNPLA2, GSN, and OR7E14P, as potential therapeutic targets through RRA analysis of RA molecular characterization, followed by MR of RA’s eQTL data and intersections. This evidence concerns the gene PNPLA2 and rheumatoid arthritis.