SEMA3C encodes a neural guidance molecule involved in several BPs, including neural development, cardiovascular formation, and tumor growth.[48] Its direct link to RA, particularly its regulation of the invasive capacity of fibroblast-like synoviocytes, suggests SEMA3C may influence RA’s severity and progression through its role in cell migration and angiogenesis. Here, SEMA3C is linked to Bartsocas-Papas syndrome 1.