In conclusion, our study identified critical genes associated with RA, including CKAP2, GABBR1, HLA-DPA1, ST6GAL1, FCGR1A, ADCY7, MAP4K1, CD37, ERAP2, SEMA3C, PNPLA2, GSN, and OR7E14P, as potential therapeutic targets through RRA analysis of RA molecular characterization, followed by MR of RA’s eQTL data and intersections. Here, CKAP2 is linked to rheumatoid arthritis.