Some researchers believe that the tumor originates from pluripotent embryonic stem cells with endocrine and/or exocrine differentiation.[16] A single-cell RNA sequencing study of SPNs in children showed that the tumor cells may originate from pancreatic endocrine progenitor cells.[17] Regarding the possibility of endocrine progenitor cells to secrete HCG, pancreatic β-cells have been reported to contain HCG/luteinizing hormone receptors.[18]. The gene discussed is LHCGR; the disease is neoplasm.