MUC5AC and colorectal adenoma: Invasive growth is a hallmark of cancer, and even in colorectal adenomas, tumors can extend in the submucosa beyond the muscularis mucosa, which is called pseudoinvasion.[7,8] This pseudoinvasion can consist only of neoplastic glands, but sometimes the neoplastic glands can cause distension owing to various degrees of luminal mucin content.