The frequency of Gln/Gln genotype in non-small cell lung cancer patients (20.7%) was significantly higher than that in the healthy control group (11.5%), and the Gln/Gln genotype was detected to increase risk in non-small cell lung cancer patients (OR = 2.63).[18] The RAD18 SNP (Arg302Gln) in these 2 studies was located in the coding region of the RAD18 gene, but we are also very interested in the genetic variations in the noncoding region. This evidence concerns the gene RAD18 and non-small cell lung carcinoma.