We found that RAD18 protein was significantly reduced in the patients with the rs615967-AG and GG genotypes, indicating that the effect of RAD18 SNP (rs615967) on cervical cancer susceptibility may be due to changes in RAD18 expression, leading to a decrease in the ability to repair damaged genomes, resulting in genomic instability and tumorigenesis.We also found that although rs250403 (A/G) located in the 3’-UTR has a higher susceptibility risk for cervical cancer (rs250403 GG with an OR = 5.089), the different genotypes of rs250403 (A/G) did not lead to differences in protein expression. Here, RAD18 is linked to cervical cancer.