In patients with elevated differentiation and lymph node metastasis (N1), the detection frequency of the Gln allele was higher.[17] Another study also found that in patients with colorectal cancer, the disease-free survival (DFS) in GG genotype patients with the RAD18 SNP of rs373572 was low. This evidence concerns the gene RAD18 and metastatic malignant neoplasm in the lymph nodes.