Compared with the control group with the Arg/Arg genotype, colorectal cancer patients with homozygous Gln/Gln (A/A) genotype showed the most significant increase in risk (OR = 2.10), and the Gln allele enhances susceptibility to colorectal cancer development.[17] Another study on 159 non-small cell lung cancer patients also showed a correlation between RAD18-Arg302Gln polymorphism and the risk of non-small cell lung cancer in humans. Here, RAD18 is linked to non-small cell lung carcinoma.