INS and Glucose intolerance: Given the lack of glucose intolerance in this cohort, it was unsurprising that antihyperglycaemic treatment did not impact basal glucose (Ptrt = 0.584) or insulin (Ptrt = 0.440) and did not improve glucose (Ptrt = 0.178) or insulin (Ptrt = 0.706) AUC following IPGTT compared to the vehicle treated group (Table 4).