MAP2K1 and glioblastoma: Existing studies have shown that bradykinin can induce AQP 4 expression and the migration and invasion of glioblastoma through B1R‐mediated calcium influx and subsequent activation of the MEK1‐ERK 1/2‐NF‐κB pathway.[32] In addition, B1R activation can also lead to Src phosphorylation and ADAM17 activation, which in turn leads to the activation of the downstream MAPK (ERK1/2, p38)‐PI3K/Akt signaling pathway, resulting in the secretion of MMP‐2/9 by human keratinocytes.[33] We detected key phosphorylated proteins in the MAPK/NF‐κB pathway, including p‐pERK1/2, p‐p38, and p‐p65.