KLK1 and neoplasm: For example, β‐catenin can promote the degradation of the ECM by activating MMPs (matrix metalloproteinases) or collagenases, providing conditions for the migration and invasion of tumor cells.[19, 20] Decorin, Fap, and β‐catenin were significantly upregulated in the inflammation‐cancer transformation model group, while KLK1 treatment significantly reduced their expression, and this improvement was inhibited in the SSR240612 group (Figure 7K,L).