Next, we collected samples from the high‐fat diet (HFD)‐induced Apcmin/+ adenoma carcinogenesis model and performed scRNA‐seq analysis (Figure S3A, Supporting Information), and we found that in the Apcmin/+ mouse model, supplementation with KLK1 inhibited colon adenoma formation, while the B1R inhibitor SSR240612 reversed this protective effect (Figure8A). This evidence concerns the gene BDKRB1 and adenoma.