In patients with non‐infectious (AP; Figure6A–C) or infectious (sepsis; Figures 2, 6) acute inflammatory injury, the expression of p‐Src in peripheral blood neutrophils, and serum NETs‐related indicators (MPO‐DNA complex and dsDNA), and pro‐inflammatory factors (IL‐6 and TNF‐α) were markedly increased compared to the healthy control group; these indicators were positively associated with poor prognosis. The gene discussed is MPO; the disease is Sepsis.