CYP46A1 and Huntington disease: High intensity CYP46A1 staining was found in the cytosol of neurons from control individuals (n = 2), whereas in HD subjects (n = 5) CYP46A1 staining in striatal neurons was weaker as assessed by quantitative measurement in two HD subjects at Vonsattel stage 3 and two HD subjects at Vonsattel stage 4.