The viral constructs for AAVrh10-CAG-HA-CYP46A1, AAVrh10-hSYN-HA-CYP46A1, and AAVrh10-GFA2-HA-CYP46A1 contained the expression cassette consisting of either the human CYP46A1 cDNA followed by human influenza HemAgglutinin tag (HA), driven by either a CMV/β-actin hybrid promoter (CAG), human synapsin (hSYN) and the Glial Fibrillary Acidic 2 (GFA2) promoter surrounded by inverted terminal repeats of AAV2. Here, CYP46A1 is linked to influenza.