MLKL and enteritis: Additionally, our findings revealed enhanced activation of necroptosis-related signaling pathways, characterized by an upregulation of necroptosis-associated signaling molecules (p-RIP1 and p-MLKL) and an increase in mRNA expression of the necroptosis-associated molecule erk. These results demonstrated that a 3% reduction in dietary protein exacerbates DSS-induced enteritis in juvenile yellow catfish.