A20, a tumor necrosis factor α-induced protein 3 (TNFAIP3) -encoded protein characterized by an N-terminal ovarian tumor (OTU) deubiquitinase domain and seven C-terminal zinc finger (ZnF) domains, acts as a potent negative regulator of the NF-κB pathway[1]. Here, TNFAIP3 is linked to ovarian neoplasm.