Notably, lactylation of the Alternative Polyadenylation (APA) regulator NUDT21 at K23 enhances its interaction with CPSF6 and promotes CFIm complex assembly, leading to 3’ UTR lengthening of FDX1 transcripts and reduced protein output, thereby promoting cuproptosis resistance in esophageal squamous cell carcinoma (ESCC) cells [75]. Here, CPSF6 is linked to esophageal squamous cell carcinoma.