In lung adenocarcinoma (LUAD), METTL3 catalyzes m6A modification of ENO1 mRNA, while YTHDF1 recognizes the m6A-modified 359 A locus and facilitates ENO1 translation, resulting in increased glucose uptake, lactate and ATP synthesis, which fuels tumor cell proliferation and accelerates LUAD progression [100]. The gene discussed is METTL3; the disease is neoplasm.