In pancreatic ductal adenocarcinoma (PDAC), H3K18 lactylation (H3K18la) transcriptionally upregulates TTK protein kinase (TTK) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), with TTK enhancing LDHA activity, thereby promoting glycolysis, increasing lactate levels, and reinforcing histone lactylation. This evidence concerns the gene TTK and pancreatic ductal adenocarcinoma.