Notably, lactylation of the Alternative Polyadenylation (APA) regulator NUDT21 at K23 enhances its interaction with CPSF6 and promotes CFIm complex assembly, leading to 3’ UTR lengthening of FDX1 transcripts and reduced protein output, thereby promoting cuproptosis resistance in esophageal squamous cell carcinoma (ESCC) cells [75]. The gene discussed is FDX1; the disease is esophageal squamous cell carcinoma.