AZD5153 mechanically and simultaneously connects to two BRD4 bromodomains, which is a different mechanism from the previous BRD4 inhibitors (such as JQ1 [34]), and exerts potent anti-tumor effects on a variety of cancers (such as hematological malignancies, prostate cancer, and colorectal cancer). The gene discussed is BRD4; the disease is prostate carcinoma.