TMPRSS3 and hearing loss disorder: This potential may be similarly applied to treating different progressive forms of hearing loss, where timely intervention is crucial to prevent irreversible damage, such as TMPRSS3-related hearing loss or the EPS8 model, where EPS8 expression could not be rescued after P2 (Abu Rayyan et al, 2020; Bademci et al, 2016; Jeng et al, 2022).