GLI2 and hydrops fetalis: The decrease in proliferation was also reflected by the differences in HF morphogenesis: whereas the majority of HF of Gli3EKO and control mice where mainly in stage 6 of HF development, follicles of Gli2EKO and Gli2/3EKO mice were still delayed at stage 4 (Fig. 1H) (Paus et al, 1999; Saxena et al, 2018).