Although NMT1 and NMT2 share ~77% sequence identity (Giang and Cravatt, 1998), NMT2 in particular plays a significant role in cardiac remodeling and heart failure, with affected patients exhibiting up to a 60% decrease in cardiomyocyte NMT2 levels compared to healthy individuals (Tomita et al, 2023). This evidence concerns the gene NMT2 and heart failure.