RYR2 and cancer: Moreover, these two SBS subtypes differed in somatic mutations in several cancer driver genes, including higher mutation frequency of ERBB2, GATA3 and FGFR4, and lower frequency of DMD, INHBA, OGDHL, PLEKHG5 and RYR2 in subtype 3 than in subtype 1 (P < 0.05; Fig. 3a).