These included 16 known TNBC genes, namely, NOTCH1 (7%), RB1 (7%), KMT2D (6%), PIK3CA (5%), PTEN (5%), KMT2C (5%), BRCA1 (5%), NF1 (5%), SPEN (4%), FAT3 (4%), CREBBP (4%), PIK3R1 (3%), NOTCH2 (3%), BRCA2 (2%), ERBB2 (2%) and KDM6A (2%), and 7 known breast cancer genes, albeit not specific to TNBC, ARID1A (4%), CIC (4%), GNAS (4%), AXIN1 (4%), RYR2 (3%), USH2A (3%) and GATA3 (2%). The gene discussed is SPEN; the disease is breast carcinoma.