To determine whether the expanded IM population seen in GEMMs is relevant in human PCa, we first verified that gene sets identified through single-cell analysis of our EPC mice are present in single-cell data from ERG+ human PCa (Fig. 4g,h, Extended Data Fig. 8a, Supplementary Table 3 and Supplementary Note 5). The gene discussed is ERG; the disease is posterior cortical atrophy.