We next asked whether ERG+ human PCa, which typically display uniform ERG expression in luminal cells, also have evidence of ERG expression in rare basal cells by annotating ERG and TMPRSS2 expression in two independent published scRNA-seq datasets of localized PCa (total PCa n = 29; ERG-positive PCa n = 9)51,52. Here, ERG is linked to posterior cortical atrophy.