IL6 and open-angle glaucoma: On the safety end, genetically downregulated IL-6 signaling via IL6 perturbation was associated with a higher risk of the following outcomes: (1) glaucoma (open-angle glaucoma, exfoliative glaucoma and use of antiglaucoma preparations), (2) retinal vascular disease, (3) pregnancy-related maternal complications (mainly antepartum and postpartum hemorrhage) and (4) a set of miscellaneous outcomes, including fertility treatment (procreative management), hydrocele, hypertrophic scar, wrist and hand fracture, migraine and cervical in situ carcinoma (Fig. 7 and Supplementary Table 14).