While there was no significant evidence of a shared causal variant in the IL6 locus in colocalization analyses for the remaining ASCVD outcomes, there was also no evidence of distinct causal variants (PP.H3 < 0.2 for all other outcomes) that would suggest bias due to pleiotropic effects of variants in linkage disequilibrium (LD) with the variants comprising our instrument (Supplementary Table 10 and Extended Data Fig. 4). This evidence concerns the gene IL6 and atherosclerosis.