We found that genetically downregulated IL-6 signaling through either IL6 or IL6R is associated with lower odds of type 2 diabetes, although the effect of IL6 perturbation was larger in magnitude (OR per 24% decrease in CRP of 0.92, 95% CI 0.90 to 0.94 for IL6 versus 0.97, 95% CI 0.95 to 0.99 for IL6R; Fig. 5a). This evidence concerns the gene CRP and type 2 diabetes mellitus.