BCR and leukemia: 7/8 ASCI-R clones harbored mutations in the KD BCR::ABL1 and 5/8 ASCI-R clones exhibited clone-specific mutations in other leukemia-associated genes including ASXL1, EZH1, GATA2, NOTCH1, SF3B1, TET2, TP53, and ZRSR2 (Fig. 1A; Supplementary Table S1A), alongside with other mutations intrinsic to KCL-22 cells (Supplementary Table S1B).