In our study, the single dose of CCR2-antagonist after 9 h of inducing an ALI by HCl/LPS instillation, that is the time when the monocyte mobilization and infiltration have already started, reduced the infiltrated monocytes in the alveolar space 24 h after the insult, but this reduction was not persistent nor sustained at 72 h, indicating that a single dose of CCR2-antagonist is not sufficient to inhibit the long-term monocyte trafficking into the alveolar space. Here, CCR2 is linked to acute respiratory distress syndrome.