Of the 22 female-specific MDD/metabolic syndrome pleiotropic regions, possible causal risk loci mapped to multiple genes (GPC6, SHISA9, RP11-154H12.3, KCNG2, TXNL4A, RBFA and ADNP2) (Supplementary Data 31). The gene discussed is TXNL4A; the disease is metabolic syndrome.