MRPL12 and nonpapillary renal cell carcinoma: Notably, we found that the proliferative and migratory effects induced by K163R mutant overexpression in ccRCC cells were effectively suppressed by treatment with a glycolysis inhibitor, suggesting that the malignant phenotype resulting from MRPL12 K163R overexpression is facilitated through enhanced glycolysis (Fig. 4J, K, and Supplementary Fig. 1A).