To assess the clinical significance of MRPL12 K163 acetylation in ccRCC tissues, we conducted immunohistochemistry (IHC) using a specific antibody against MRPL12 K163 acetylation on tissue microarrays from 90 ccRCC patients, as well as paired ccRCC and adjacent normal tissue (NTL) samples from 81 patients. The gene discussed is MRPL12; the disease is nonpapillary renal cell carcinoma.